Elabela (19-32) [CAS 1886973-05-2]

Elabela (19-32) is an active fragment of ELABELA (ELA) that binds to apelin receptor (APJ) . Elabela (19-32) activates the Gαi1 and β-arrestin-2 signaling pathways with EC50s of 8.6 nM and 166 nM. Elabela (19-32) induces receptor internalization and reduces arterial pressure, exerts positive inotropic effects on the heart[1].

[1886973-05-2]

C75H119N25O17S2

1707.03

O=C([C@@H]1CCC(N1)=O)N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CS)C(N[C@@H](CCSC)C(N2[C@@H](CCC2)C(N[C@@H](CC(C)C)C(N[C@H](C(N[C@@H](CO)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](C(C)C)C(N3[C@@H](CCC3)C(N[C@@H](CC4=CC=CC=C4)C(N5[C@@H](CCC5)C(O)=O)=O)=O)=O)=O)=O)=O)CC6=CN=CN6)=O)=O)=O)=O)=O)=O

Apelin Receptor (APJ) ; Arrestin

99.64

H2O : 100 mg/mL (ultrasonic)

-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

Blue Ice