Elesclomol [CAS 488832-69-5]

Elesclomol (STA-4783) is a potent copper ionophore and promotes copper-dependent cell death (cuproptosis) . Elesclomol specifically binds ferredoxin 1 (FDX1) α2/α3 helices and β5 strand. Elesclomol inhibits FDX1-mediated Fe-S cluster biosynthesis. Elesclomol is an oxidative stress inducer that induces cancer cell apoptosis. Elesclomol is a reactive oxygen species (ROS) inducer. Elesclomol can be used for Menkes and associated disorders of hereditary copper deficiency research[1][2][3][4].

[488832-69-5]

C19H20N4O2S2

400.52

S=C(C1=CC=CC=C1)N(NC(CC(NN(C(C2=CC=CC=C2)=S)C)=O)=O)C

Apoptosis; Cuproptosis; Reactive Oxygen Species (ROS)

99.43

DMSO : 100 mg/mL (ultrasonic)

-20°C, 3 years; 4°C, 2 years (Powder)

Room Temperature

H302, H312, H315, H319, H332, H335

H302, H312, H315, H319, H332, H335