Eleven-Nineteen-Leukemia Protein IN-3 [CAS 2894121-83-4]

Eleven-Nineteen-Leukemia Protein IN-3 is an orally active inhibitor of ENL YEATS domain with an IC50 value of 15.4 nM. Eleven-Nineteen-Leukemia Protein IN-3 down-regulates MYC expression through ENL in cells and can enhances the thermal stability of ENL protein in vitro[1].

[2894121-83-4]

C28H27N5O2

465.55

C[C@H]1CCCN1CC2=NC3=CC(NC(C4=CC=C5C(C6=CC=CC=C6C(N5C)=O)=C4)=O)=CC=C3N2

Epigenetic Reader Domain

10 mM in DMSO

Room temperature