ELQ-121 [CAS 1228283-36-0]

ELQ-121 is a potent inhibitor of the ubiquinol-oxidation (QO) -site of parasites. ELQ-121 has IC50 of 0.05 nM against chloroquine sensitive and multidrug resistant P. falciparum in vitro. ELQ-121 inhibits T. gondii and N. caninum with IC50 below 1 nM in vitro. ELQ-121 suppresses B. besnoiti tachyzoite proliferation with an IC50 of 0.49 nM and induces mitochondrial disruption. ELQ-121 can form polyethylene glycol carbonate ester prodrug which demonstrates in vivo efficacy against P. yoelii in mice. ELQ-121 is suitable for antimalarial research[1][2][3].

[1228283-36-0]

C17H21F2NO

293.35

FC1=C2C(NC(C)=C(CCCCCCC)C2=O)=CC(F)=C1

Parasite

Room temperature