EMD-66684 (potassium salt) [CAS 187683-79-0]

EMD-66684 potassium salt is a non-peptide angiotensin II receptor antagonist that demonstrates significant antihypertensive effects in spontaneously hypertensive rats. EMD-66684 potassium salt exhibits nanomolar affinity for angiotensin II receptors, comparable to losartan in potency. EMD-66684 potassium salt shows increased activity when modified with acetamides, leading to superior blood pressure reduction.

[187683-79-0]

C28H29KN8O2

548.68

O=C1C2=C(C=CN1CC(N(C)C)=O)N=C(CCCC)N2CC3=CC=C(C4=C(C5=NN=N[N-]5)C=CC=C4)C=C3.[K+]

Angiotensin Receptor

Room temperature