Emodin-d4 [CAS 132796-52-2]

Emodin-d4 is the deuterium labeled Emodin. Emodin (Frangula emodin), an anthraquinone derivative, is an anti-SARS-CoV compound. Emodin blocks the SARS coronavirus spike protein and angiotensin-converting enzyme 2 (ACE2) interaction[1]. Emodin inhibits casein kinase-2 (CK2) . Anti-inflammatory and anticancer effects[2]. Emodin is a potent selective 11β-HSD1 inhibitor with the IC50 of 186 and 86 nM for human and mouse 11β-HSD1, respectively. Emodin ameliorates metabolic disorder in diet-induced obese mice[3].

[132796-52-2]

C15H6D4O5

274.26

O=C1C2=C(O)C([2H])=C(C)C([2H])=C2C(C3=C([2H])C(O)=C([2H])C(O)=C31)=O

11β-HSD; Autophagy; Casein Kinase; Isotope-Labeled Compounds; SARS-CoV

10 mM in DMSO

Room temperature