Emoquine-1

Emoquine-1 is an orally active and potent antimalarial drug. Emoquine-1 is efficient against multidrug-resistant Plasmodium parasites, including the Artemisinin-resistant quiescent stage. Emoquine-1 is active against proliferative P. falciparum with IC50 values of 20-55 nM. Emoquine-1 is a candidate to fight Plasmodium parasites resistant to artemisinin-based combination therapies (ACTs) with a capacity to eliminate persistent parasites[1].

C30H28ClN3O6

562.01

CC1=CC(C(C2=C3C(O)=CC(OCCOCCNCCNC4=CC=NC5=C4C=CC(Cl)=C5)=C2)=O)=C(C(O)=C1)C3=O

Parasite

Room temperature