Endo-S-cGAFMP

Endo-S-cGAFMP (Compound 3) is a STING agonist. endo-S-cGAFMP induces the production of interferon regulatory factors and proinflammatory cytokines by activating the cGAS-STING pathway, thereby enhancing innate and adaptive immune responses. endo-S-cGAFMP has potent immunostimulatory capacity in THP1 monocytes and RAW macrophages (EC50 values of 2.45 μM and 5.54 μM, respectively) . endo-S-cGAFMP has significant antitumor activity. endo-S-cGAFMP can be used as a potential cancer immunotherapeutic agent, especially for studies of systemic administration[1].

C20H23FN10O11P2S

692.47

F[C@@H]1[C@H](O2)[C@@H](CSP(O)(O[C@@H]3[C@H](O)[C@@H](COP2(O)=O)O[C@H]3N(C=N4)C5=C4C(NC(N)=N5)=O)=O)O[C@H]1N6C=NC7=C6N=CN=C7N

STING

Room temperature