Enpp-1/3-IN-1

Enpp-1/3-IN-1 (Compound 5j) is an ENPP1/ENPP3 inhibitor, with IC50s of 0.59 μM (h-ENPP1) and 0.62 μM (h-ENPP3) respectively. Enpp-1/3-IN-1 also inhibits e5′NT (CD73) and TNAP with IC50s of 0.89 μM (h-e5′NT), 5.12 μM (r-e5′NT) and 1.68 μM (h-TNAP), respectively. Enpp-1/3-IN-1 can be used for cancer research[1].

C17H13F3N2O4S

398.36

O=C(CC1=CNC2=CC=CC=C21)NC3=CC=CC=C3OS(C(F)(F)F)(=O)=O

CD73; Phosphatase; Phosphodiesterase (PDE)

Room temperature