Enpp-1-IN-20 [CAS 3029600-37-8]

Enpp-1-IN-20 (Compound 31) is an ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) inhibitor, with an IC50 of 0.09 nM. Enpp-1-IN-20 has strongest inhibitory activity in the cell-based assay, with an IC50 of 8.8 nM. Enpp-1-IN-20 has significant potency in both ENPP1 inhibition and STING pathway stimulation in vitro. Enpp-1-IN-20 can be used for the research of cancer[1].

[3029600-37-8]

C14H17N4O4P

336.28

O=C1NC(N=CN=C2N3C[C@@]4([C@]([H])(C3)[C@H]4CCP(O)(O)=O)[H])=C2C=C1

Phosphodiesterase (PDE) ; STING

98.06

DMSO : 1.92 mg/mL (ultrasonic; adjust pH to 2 with 1 M HCl)

-20°C, 3 years (Powder)

Blue Ice