Ensifentrine-d6

Ensifentrine-d6 (RPL-554-d6) is deuterium labeled Ensifentrine. Ensifentrine (RPL-554) is an inhaled first-in-class dual inhibitor of phosphodiesterase 3 (PDE3) and PDE4 with IC50s of 0.4 nM and 1479 nM, respectively. Ensifentrine has bronchoprotective and anti-inflammatory activities. Ensifentrine can be used for chronic obstructive pulmonary disease (COPD) research[1][2].

C26H25D6N5O4

483.59

O=C1N2C(C3=CC(OC([2H])([2H])[2H])=C(OC([2H])([2H])[2H])C=C3CC2)=C/C(N1CCNC(N)=O)=N\C4=C(C=C(C=C4C)C)C

Isotope-Labeled Compounds; Phosphodiesterase (PDE)

Room temperature