Entacapone-d10 [CAS 1185241-19-3]

Entacapone-d10 is the deuterium labeled Entacapone. Entacapone is a potent, reversible, peripherally acting and orally active catechol-O-methyltransferase (COMT) inhibitor. Entacapone inhibits COMT from rat brain, erythrocytes and liver with IC50 values of 10 nM, 20 nM, and 160 nM, respectively. Entacapone is selective for COMT over other catecholamine metabolizing enzymes, including MAO-A, MAO-B, phenolsulphotransferase M (PST-M) and PST-P (IC50s>50 μM) . Entacapone can be used for the research of Parkinson's disease[1]. Entacapone serves as a inhibitor of FTO demethylation with an IC50 of 3.5 μM, can be used for the research of metabolic disorders[2].

[1185241-19-3]

C14H5D10N3O5

315.35

OC1=C([N+]([O-])=O)C=C(/C=C(C#N)/C(N(C([2H])([2H])C([2H])([2H])[2H])C([2H])([2H])C([2H])([2H])[2H])=O)C=C1O

COMT

98

10 mM in DMSO|DMSO : 33.33mg/mL (ultrasonic) |H2O : 2mg/mL (ultrasonic; adjust pH to 10 with NaOH)

-20°C (Powder, sealed storage, away from moisture)

Blue Ice