EP300/CBP-IN-1 [CAS 2638507-71-6]

EP300/CBP-IN-1 (compound 172) is a potent EP300/CBP inhibitor with IC50s of 2.3 nM and 2.1 nM for CBP BRD and EP300 BRD, respectively. EP300/CBP-IN-1 has the inhibitory effect on the proliferation of prostate cancer CWR22RV1 cells[1].

[2638507-71-6]

C30H32ClFN4O4

567.05

O=C1N(C2=CC(F)=C(C=C2)Cl)[C@@H](CCO1)C3=NC4=CC(C5=C(C)ON=C5C)=CC=C4N3[C@H]6CC[C@@H](CC6)OCC

Epigenetic Reader Domain; Histone Acetyltransferase

10 mM in DMSO

Room temperature