EPIC-0628

EPIC-0628 is an inhibitor of the HOTAIR-EZH2 interaction and promotes ATF3 expression. The long noncoding RNA HOTAIR has been found to regulate glioblastoma (GBM) progression and mediate DNA damage repair (DDR) by interacting with the catalytic subunit EZH2 of PRC2. EPIC-0628 also inhibits the ATF3-p38-E2F1 DDR pathway to inhibit the HR pathway and upregulates CDKN1A (p21) expression, causing cell cycle arrest. EPIC-0628 also synergizes with Temozolomide (TMZ) to enhance its in vivo potency[1].

C20H17F4N3O

391.36

FC(F)(F)C(C1=C2CNCC1)=NN2CC3=CC=CC(OC4=CC=C(F)C=C4)=C3

Histone Methyltransferase

EZH2

98.93

DMSO : 200 mg/mL (ultrasonic)

-20°C, 3 years; 4°C, 2 years (Powder)

Room Temperature