Eplerenone (Epoxymexrenone) is a selective, highly specific and orally active aldosterone blocker (SAB) . Eplerenone also is a selective mineralocorticoid receptor antagonist (MRA) with IC50 value of 0.081 μM. Eplerenone can be used for the research of hypertension, atherosclerosis, chronic systolic heart failure (HF) and cardiovascular (CV) [1][2].