Epoxomicin [CAS 134381-21-8]
Epoxomicin [CAS 134381-21-8]
SKU:QM-0146224-01
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Product Details
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Description
Epoxomicin (BU-4061T) is an epoxyketone-containing natural product and a potent, selective and irreversible proteasome inhibitor. Epoxomicin covalently binds to the LMP7, X, MECL1, and Z catalytic subunits of the proteasome and potently inhibits primarily the chymotrypsin-like activity. Epoxomicin can cross the blood-brain barrier. Epoxomicin has strongly antitumor and anti-inflammatory activity[1][2][3][4][5].
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CAS Number
[134381-21-8]
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Molecular Formula
C28H50N4O7
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Molecular Weight
554.72
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Smiles
O=C([C@@H](NC([C@H]([C@@H](C)O)NC([C@@H](NC([C@H]([C@@H](C)CC)N(C)C(C)=O)=O)[C@@H](C)CC)=O)=O)CC(C)C)[C@@]1(C)CO1
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Target
Apoptosis; Proteasome
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Purity
99.6
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Solubility
DMSO : 100 mg/mL (ultrasonic)
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Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
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Shipping Conditions
Room Temperature
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Epoxomicin [CAS 134381-21-8]
Epoxomicin is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.