ER degrader 6 [CAS 2922929-62-0]

ER degrader 6 (compound 35s) is a potent Estrogen Receptor (ER) α degrader. ER degrader 6 disrupts the microtubule network by restraining tubulin polymerization. ER degrader 6 suppresses tumor growth without noticeable poisonousness[1].

[2922929-62-0]

C33H34FN3O5SSe

682.66

O=C(CCCCC[Se]C#N)NC1=CC=C(C2=C(C3=CC=C(O)C=C3)[C@H]4CC(S(N(CC)C5=C(F)C=CC=C5)(=O)=O)[C@@H]2O4)C=C1

Estrogen Receptor/ERR

ERα

10 mM in DMSO

Room temperature