ERD-12310A

ERD-12310A is a PROTAC targeting Estrogen Receptor α (ERα) with a ED50 value of 47 pM. ERD-12310A has oral activity. ERD-12310A is composed of PROTAC target protein ligand ER ligand-4 (red part), E3 ligase ligand (S) -Deoxy-thalidomide (HY-168055) (blue part). ERD-12310A can be used in the research of ER+ breast cancer[1].

C51H56N4O6

821.01

O=C(N1)[C@H](CCC1=O)N(C2=O)CC3=C2C=CC4=C3OCC45CCN(CC5)C[C@H]6COC7(CC6)CCN(CC7)C8=CC=C(C=C8)[C@H]9[C@H](CCC%10=C9C=CC(O)=C%10)C%11=CC=CC=C%11

Estrogen Receptor/ERR; PROTACs

Room temperature