ES 6864 [CAS 116326-39-7]

ES 6864 is an orally active, competitive inhibitor for human renin, with an IC50 of 6.9 nM and a Ki of 7.3 nM. ES 6864 exhibits high species-specific and enzyme-specific properties. ES 6864 exhibits metabolic stability in rat tissue homogenates. ES 6864 reduces blood pressure in rats and sodium-depleted awake marmosets[1].

[116326-39-7]

C42H58N6O7S

791.01

O=C(N1CCOCC1)C[C@H](C(N[C@H](C(N[C@@H](CC2CCCCC2)[C@@H](O)CC(NCCN3CCOCC3)=O)=O)CC4=CSC=N4)=O)CC5=CC=CC6=C5C=CC=C6

Renin

Room temperature