Estetrol-d4 (Major) [CAS 2734920-42-2]

Estetrol-d4 (Major) is the deuterium labeled Estetrol. Estetrol, an orally active estrogen synthesized exclusively during pregnancy by the human fetal liver, is a selective nuclear estrogen receptor modulator. Estetrol binds ERα as well as ERβ (with a fourfold lower affinity). Estetrol increases eNOS expression/activity and NO synthesis in endothelial cells. Estetrol exerts estrogenic actions on the endometrium or the central nervous system but presents antagonistic effects on the breast. Estetrol can be used in contraception and menopausal hormone research[1][2][3][4].

[2734920-42-2]

C18H20D4O4

308.41

[2H]C1=C(C([2H])=C(C2=C1)C([2H])(C[C@@]3([C@@]2(CC[C@]4([C@]3([C@H]([C@H]([C@@H]4O)O)O)[H])C)[H])[H])[2H])O

Endogenous Metabolite; Estrogen Receptor/ERR; Isotope-Labeled Compounds; NO Synthase

Room temperature