Exemestane-d2

Exemestane-d2 is the deuterium labeled Exemestane. Exemestane (FCE 24304) is a selective, irreversible and orally active steroidal aromatase inhibitor with IC50s of 30 nM and 40 nM for human placental and rat ovarian aromatase, respectively. Exemestane can be used for hormone-dependent breast cancer research[1][2].

C20H22D2O2

298.42

C[C@@]12[C@]3([H])[C@](CC(C1=CC(C=C2)=O)=C)([H])[C@@]4([H])[C@](CC3)(C(C([2H])([2H])C4)=O)C

Cytochrome P450; Isotope-Labeled Compounds

Aromatase/CYP19A1

10 mM in DMSO

Room temperature