FabX-IN-1

FabX-IN-1 (Compound 47) is a selective FabX inhibitor with an IC50 of 0.128 μM. FabX-IN-1 has a narrow-spectrum antibacterial activity against Helicobacter pylori with a MIC of 64 μg/mL, but significantly enhances synergistic inhibitory efficacy combined with membrane permeabilizers, efflux pump inhibitors, and Clarithromycin. FabX-IN-1 can be used for bacterial infections research[1].

C21H19N5O3S2

453.54

O=C(NC1=NN=C(S(=O)(NC2=CC=CC(N(C)C)=C2)=O)S1)C3=CC=C4C=CC=CC4=C3

Bacterial

Room temperature