FAK-IN-12

FAK-IN-12 (Compound 12S) is a FAK inhibitor (IC50 = 47 nM) . FAK-IN-12 inhibits MGC-803, HCT-116 and KYSE30 cell proliferation (IC50: 0.24, 0.45, 0.44 μM) . FAK-IN-12 induces apoptosis and cellular senescence[1].

C25H25ClN6O3

492.96

O=C(C1=CC=CC=C1NC2=C(C=NC(NC3=CC=C(C=C3)/C=C/C(N4CCOCC4)=O)=N2)Cl)NC

FAK

10 mM in DMSO

Room temperature