FB49

FB49 is a highly selective inhibitor of Bcl-2-associated athanogene 3 (BAG3), with the Ki of 45 μM. FB49 inhibits the cell growth in human tumoral cells, but has no toxicity in human peripheral mononuclear cells. FB49 block cell cycle in G1 phase and to induce apoptosis as well as autophagy in medulloblastoma HD-MB03 treated cells[1].

C17H18N2O6S

378.4

O=C(N(C(C)C(N1CCOCC1)=O)C/2=O)SC2=C/C3=CC=CC(O)=C3O

Apoptosis; Autophagy

99.76

DMSO : 100 mg/mL (ultrasonic)

-20°C, 3 years (Powder)

Blue Ice