FD-IN-1 [CAS 1646682-14-5]

FD-IN-1 (Compound 12) is an orally bioavailable and selective factor D (FD) inhibitor with an IC50 of 12 nM. Complement FD, a highly specific S1 serine protease, plays a central role in the alternative complement pathway of the innate immune system. FD-IN-1 also inhibits factor XIa (FXIa) and Tryptase β2 with IC50s of 7.7 and 6.5 μM, respectively[1].

[1646682-14-5]

C23H23NO4

377.43

O=C(O)CC1=CC=CC=C1OCC2=CC=CC(C3=CC([C@H](N)CO)=CC=C3)=C2

Complement System

99.24

DMSO : 62.5 mg/mL (ultrasonic; warming; heat to 80°C)

-20°C, 3 years; 4°C, 2 years (Powder)

Room Temperature