FD1024 [CAS 1422456-47-0]

FD1024 is PIM inhibitor (IC50s: 1.96, 38.9, 4.17 nM for PIM1, 2, 3) . FD1024 can be used for research of acute myeloid leukemia. FD1024 has strong antiproliferative activity against the tested AML cell lines, with 0.16 μM, 0.12 μM, 1.05 μM, 1.39μM for EOL-1, MV-4-11, KG-1, MOLM-16 cells. FD1024 also has antitumor efficacy in mice[1].

[1422456-47-0]

C21H20F2N4O2S

430.47

O=C(C1=CSC(C2=C(F)C=CC=C2F)=N1)NC3=C(O[C@H]4CC[C@H](N)CC4)C=CN=C3

Pim

10 mM in DMSO

Room temperature