FDU73

FDU73 is a highly effective and selective BTK PROTAC degrader with a DC50 of 2.9 nM (in JeKo-1 cells). FDU73 can inhibit the proliferation of tumor cells and exhibits anti-tumor activity[1]. (Pink: BTK ligand-14 ; Black: Linker (HY-168297) ; Blue: E3 ligase ligand 59 (HY-173378) ; E3 ligase ligand+Linker (HY-173127) )

C48H55N9O5

838.01

O=C(N[C@@H]1C[C@@H](NC2=C3C(NC=C3C(C4=CC=C(OC5=CC=CC=C5)C=C4)=O)=NC=N2)CC1)CC6CCN(CCC7CCN(C8=NC=C(C(CC9)C(NC9=O)=O)C=C8)CC7)CC6

Btk; PROTACs

Room temperature