Feralolide [CAS 149418-38-2]

Feralolide is a dihydroisocoumarin isolated from the methanolic extract of aloe vera resin. Feralolide is also a dual inhibitor of AChE and BuChE, with IC50s of 55 μg/mL and 52 μg/mL respectively. Feralolide has antioxidant activity and inhibits 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2, 2′-azinobis-3-ethylbenzothiazoline-6-sulfonic acid (ABTS) . Feralolide could be used in research into cognitive disorders such as Alzheimer's disease, potentially restoring and enhancing memory[1].

[149418-38-2]

C18H16O7

344.32

O=C1C2=C(O)C=C(O)C=C2C[C@H](O1)CC3=C(C(O)=CC(O)=C3)C(C)=O

Cholinesterase (ChE)

10 mM in DMSO

Room temperature