FGFRs-IN-1
FGFRs-IN-1
SKU:QM-0009646
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Product Details
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Description
FGFRs-IN-1 (Compound A16) is the orally active inhibitor for FGFR, that inhibits FGFR1/2/3/4 with IC50s of 2.3, 7, 11, and 163 nM, respectively. FGFRs-IN-1 also inhibits VEGFR1/2/3, Abl, and Flt3 with IC50s of 61, 176, 112, 26, and 353 nM, respectively. FGFRs-IN-1 exhibits weak inhibitory efficacy against CYP enzymes. FGFRs-IN-1 reduces the expression of α-SMA and collagen I, and inhibits epithelial-mesenchymal transition (EMT) in TGF-β1 stimulated A549 cell. FGFRs-IN-1 exhibits anti-inflammatory activity in Bleomycin -induced mouse pulmonary fibrosis model and CCl4 (HY-Y0298) -induced mouse liver fibrosis model[1].
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Molecular Formula
C28H26Cl2N4O3
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Molecular Weight
537.44
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Smiles
O=C(C1=CC=C(/C=C/C2=NNC3=C2C=CC(C4=C(Cl)C(OC)=CC(OC)=C4Cl)=C3)C=C1)N5CCNCC5
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Target
Bcr-Abl; Cytochrome P450; FGFR; FLT3; VEGFR
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Isoform
Abl; CYP1A2; CYP2C19; CYP2D6; VEGFR1/Flt-1; VEGFR2/KDR/Flk-1; VEGFR3/Flt-4
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Shipping Conditions
Room temperature
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FGFRs-IN-1
FGFRs-IN-1 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.