FKB04 is a telomeric repeat binding factor 2 (TRF2) inhibitor that exerts its antitumor activity by disrupting the telomere maintenance mechanism in liver cancer cells, leading to T-loop defects, telomere shortening, and cellular senescence. Additionally, FKB04 can inhibit tumor growth in a human liver cancer xenograft mouse model (with Huh-7 cells implanted in BALB/c mice) . FKB04 can be used in liver cancer research[1].
Molecular Formula
C17H15BrO4
Molecular Weight
363.2
Smiles
BrC1=CC(/C=C/C(C2=C(C=C(C=C2O)OC)OC)=O)=CC=C1
Target
Telomerase
Purity
99.98
Solubility
DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)