FLT3/CHK1-IN-1 [CAS 2991054-23-8]

FLT3/CHK-IN-1 (Compound 18) is a dual inhibitor of FLT3/CHK1. FLT3/CHK-IN-1 is more than 1700 times more selective to c-KI T and greatly reduces hERG affinity with an IC50 value of 58.4 μM. FLT3/CHK-IN-1 inhibits tumor growth in mouse xenotransplantation models inoculated with MV-4-11 cells[1].

[2991054-23-8]

C25H33F3N6O2

506.56

N[C@H]1CC[C@@H](NC2=NC(NC3=CC4=C(C=C3)CN(C(CC(O)(C)C)=O)CC4)=NC=C2C(F)(F)F)CC1

FLT3

98

DMSO : 100 mg/mL (ultrasonic)

4°C (Powder, protect from light)

Room Temperature