FLT3-IN-12 [CAS 2499966-67-3]

FLT3-IN-12 is a potent, selective and orally active FLT3 kinase inhibitor with IC50s of 1.48 nM and 2.87 nM for FLT3-WT and FLT3-D835Y, respectively. FLT3-IN-12 possesses high selectivity over c-KIT (>1000-fold) . FLT3-IN-12 has an excellent anti-AML (acute myeloid leukemia) activity (MV4-11, IC50 of 0.75 nM) [1].

[2499966-67-3]

C21H23F3N6O

432.44

O=C1C2=CC=C(NC3=NC=C(C(F)(F)F)C(N[C@@H]4CC[C@@H](CC4)N)=N3)C=C2C=CN1C

FLT3

10 mM in DMSO

Room temperature