FLT3-ITD-IN-3 [CAS 3018150-80-3]

FLT3-ITD-IN-3 (13v), an orally active FLT3-ITD (FLT3 internal tandem duplication) inhibitor, disrupts FLT3 signal transduction and induced G0/G1 cell cycle arrest and apoptosis. FLT3-ITD-IN-3 (13v) is used in the research of acute myeloid leukemia (AML) [1].

[3018150-80-3]

C27H21ClF2N6O5

582.94

O=C(C(C(C)=C1)=NN(C2=CC(Cl)=CC=C2F)C1=O)NC3=CC=C(OC4=CC(NC(N5CC(O)C5)=O)=NC=C4)C(F)=C3

Apoptosis; FLT3

Room temperature