Fluorofenidone [CAS 848353-85-5]
Fluorofenidone [CAS 848353-85-5]
SKU:QM-0140191-01
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Product Details
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Description
Fluorofenidone (AKF-PD) is an orally active compound with anti-fibrotic, antioxidant, and anti-inflammatory pharmacological effects. Fluorofenidone downregulates the expression of ACSL4, upregulates GPX4 expression and inhibits the NF-κB signaling pathway to alleviate inflammation and fibrosis. Fluorofenidone ameliorates cholestasis and fibrosis by inhibiting hepatic Erk/-Egr-1 signaling and Tgfβ1/Smad pathway in mice. Fluorofenidone demonstrates protective effects against chronic lung injury in mice. Fluorofenidone can be used for the study of chronic obstructive pulmonary disease (COPD), pulmonary interstitial fibrosis (PIF) and non-small cell lung cancer (NSCLC) [1][2][3].
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CAS Number
[848353-85-5]
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Molecular Formula
C12H10FNO
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Molecular Weight
203.21
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Smiles
O=C1C=CC(C)=CN1C2=CC=CC(F)=C2
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Target
ERK; NF-κB; TGF-beta/Smad
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Purity
99.78
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Solubility
DMSO : 140 mg/mL (ultrasonic)
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Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
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Shipping Conditions
Room Temperature
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Hazard Statement
H302, H315, H319, H335
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Precautions
H302, H315, H319, H335
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Fluorofenidone [CAS 848353-85-5]
Fluorofenidone is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.