Fluorofenidone-d3
Fluorofenidone-d3
SKU:QM-0140192-01
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Product Details
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Description
Fluorofenidone-d3 (AKF-PD-d3) is deuterium labeled Fluorofenidone (AKF-PD). Fluorofenidone is an orally active compound with anti-fibrotic, antioxidant, and anti-inflammatory pharmacological effects. Fluorofenidone downregulates the expression of ACSL4, upregulates GPX4 expression and inhibits the NF-κB signaling pathway to alleviate inflammation and fibrosis. Fluorofenidone ameliorates cholestasis and fibrosis by inhibiting hepatic Erk/-Egr-1 signaling and Tgfβ1/Smad pathway in mice. Fluorofenidone demonstrates protective effects against chronic lung injury in mice. Fluorofenidone can be used for the study of chronic obstructive pulmonary disease (COPD), pulmonary interstitial fibrosis (PIF) and non-small cell lung cancer (NSCLC)[2][3].
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Molecular Formula
C12H7D3FNO
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Molecular Weight
206.23
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Smiles
O=C1C=CC(C)=CN1C2=C([2H])C=C([2H])C(F)=C2[2H]
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Target
ERK; Isotope-Labeled Compounds; NF-κB; TGF-beta/Smad
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Solubility
10 mM in DMSO
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Shipping Conditions
Room temperature
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Fluorofenidone-d3
Fluorofenidone-d3 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.