FM19G11 [CAS 329932-55-0]

FM19G11 is a hypoxia-inducible factor-1-alpha (HIF-1α) inhibitor, and it inhibits hypoxia-induced luciferase activity with an IC50 of 80 nM in HeLa cells. FM19G11 modulates other signaling pathways, including mTOR and PI3K/Akt/eNOS, when the HIF-1α pathway is inactivated under normoxic conditions[1][2].

[329932-55-0]

C23H17N3O8

463.4

O=C(OCC(C1=CC=C(C)C=C1)=O)C2=CC=CC(NC(C3=CC=C([N+]([O-])=O)C=C3[N+]([O-])=O)=O)=C2

HIF/HIF Prolyl-Hydroxylase

98.39

DMSO : 100 mg/mL (ultrasonic)

4°C (Powder, protect from light)

Room Temperature

H228, H315, H319

H228, H315, H319