Fmoc-His (3-Me) -OH [CAS 252049-16-4]
Fmoc-His (3-Me) -OH [CAS 252049-16-4]
SKU:QM-0196212-01
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Product Details
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Description
Fmoc-His (3-Me) OH derives Histidine-associating compounds with biological activity. Fmoc-His (3-Me) OH, with Fmoc-citrulline-OH, Fmoc-His (1-Me) -OH together, forms tri-peptides and shows vasodilating effect with EC50s of 2.7-4.7 mM in 1.0 mM Phenylephrine (PE) -contracted aorta rings. Fmoc-His (3-Me) OH (resin) also makes Methyl-His-Gly-Lys (His (3-Me) -Gly-Lys), thus acts as an [Ca2+]i inhibitor. Fmoc-His (3-Me) OH methylates NAHIS02, making it unable to block the Alzheimer's Aβ channel[1][2][3].
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CAS Number
[252049-16-4]
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Molecular Formula
C22H21N3O4
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Molecular Weight
391.42
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Smiles
O=C(O)[C@H](CC1=CN=CN1C)NC(OCC2C3=C(C4=C2C=CC=C4)C=CC=C3)=O
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Target
Amino Acid Derivatives; Amyloid-β
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Purity
99.91
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Solubility
DMSO : 10 mg/mL (ultrasonic; warming; heat to 60°C)
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Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
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Shipping Conditions
Room Temperature
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Hazard Statement
H302, H312, H332
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Precautions
H302, H312, H332
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Fmoc-His (3-Me) -OH [CAS 252049-16-4]
Fmoc-His (3-Me) -OH is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.