Fmoc-L-Asn (EDA-N3) -OH [CAS 2616562-74-2]
Fmoc-L-Asn (EDA-N3) -OH [CAS 2616562-74-2]
SKU:QM-0069656
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Product Details
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Description
Fmoc-L-Asn (EDA-N3) -OH is a click chemistry reagent containing an azide group. This building block is reported in literature for the modification of Amanitin via Click Chemistry. Alpha-Amanitin is the deadliest member of the amatoxin peptide family produced by the death-cap mushroom A. phalloides. It is an orally available, rigid, bicyclic octapeptide and one of the most lethal known natural products (LD50 = 50-100 μg/kg) acting as highly selective allosteric inhibitor of the RNA polymerase II[1]. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
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CAS Number
[2616562-74-2]
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Molecular Formula
C21H21N5O5
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Molecular Weight
423.42
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Smiles
[N-]=[N+]=NCCNC(C[C@@H](C(O)=O)NC(OCC1C2=CC=CC=C2C3=CC=CC=C31)=O)=O
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Target
ADC Linker
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Solubility
10 mM in DMSO
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Shipping Conditions
Room temperature
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Fmoc-L-Asn (EDA-N3) -OH [CAS 2616562-74-2]
Fmoc-L-Asn (EDA-N3) -OH is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.