FNDR-20123 (free base) [CAS 1267502-34-0]

FNDR-20123 free base is a safe, first-in-class, and orally active anti-malarial HDAC inhibitor with IC50s of 31 nM and 3 nM for Plasmodium and human HDAC, respectively. FNDR-20123 free base exerts anti-malarial activity against Plasmodium falciparum asexual stage (IC50=41 nM) and sexual blood stage (IC50=190 nM for male gametocytes) . FNDR-20123 free base inhibits HDAC1, HDAC2, HDAC3, HDAC6, and HDAC8 (IC50=25, 29, 2, 11, and 282 nM, respectively) and inhibits Class III HDAC isoforms at nanomolar concentrations[1].

[1267502-34-0]

C21H23N5O2

377.44

O=C(NO)C1=CC=C(CN2N=NC(C3=CC=C(CN4CCCC4)C=C3)=C2)C=C1

HDAC; Parasite

HDAC; HDAC1; HDAC2; HDAC3; HDAC6; HDAC8; Plasmodium

DMSO : 35.71 mg/mL (ultrasonic)

Room temperature