Forigerimod [CAS 497156-60-2]

Forigerimod (IPP-201101) is a CD4 T-cell modulator. Forigerimod is a 21-amino-acid fragment of U1 small nuclear ribonucleoprotein 70 kDa that is phosphorylated at Ser140. Forigerimod can potently inhibit autophagy. Forigerimod can be used for the research of autoimmune disorders, such as systemic lupus erythematosus (SLE) [1][2][3][4].

[497156-60-2]

C117H181N34O32PS

2638.94

OC(C=C1)=CC=C1C[C@H](NC([C@H](C(C)C)NC([C@H](CCSC)NC([C@@H](NC([C@H]([C@@H](C)CC)NC([C@@H](N)CCCNC(N)=N)=O)=O)CC2=CN=CN2)=O)=O)=O)C(N[C@@H](CO)C(N[C@@H](CCCCN)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](COP(O)(O)=O)C(NCC(N[C@@H](CCCCN)C(N3[C@@H](CCC3)C(N[C@@H](CCCNC(N)=N)C(NCC(N[C@H](C(N[C@@H](C)C(N[C@H](C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CCC(O)=O)C(N[C@H](C(O)=O)CC4=CC=C(C=C4)O)=O)=O)=O)CC5=CC=CC=C5)=O)=O)CC6=CC=C(C=C6)O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O

Autophagy

10 mM in DMSO

Room temperature