Foxy-5 (TFA)

Foxy-5 TFA, a WNT5A agonist, is a mimicking peptide of WNT5A which is a non-canonical member of the Wnt family. Foxy-5 TFA triggers cytosolic free calcium signaling without affecting β-catenin activation and it impairs the migration and invasion of epithelial cancer cells. Foxy-5 TFA effectively reduces the metastatic spread of WNT5A-low prostate cancer cells in an orthotopic mouse model[1][2][3].

C28H43F3N6O14S2

808.8

O=C([C@H](CS)NC(CNC([C@H](CC(O)=O)NC([C@@H](NC=O)CCSC)=O)=O)=O)N[C@@H](CCC(O)=O)C(N[C@H](C(O)=O)CC(C)C)=O.OC(C(F)(F)F)=O

Wnt

Wnt5

99.17

DMSO : ≥ 100 mg/mL|H2O : 3.33 mg/mL (ultrasonic)

-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

Blue Ice