FPP29

FPP29 is a novel, efficient, and safe peptide based FOXM1 PROTAC degrader. FPP29 significantly inhibits cell scratch healing, induces apoptosis, and suppresses clone formation. FPP29 has cytotoxicity (IC50 = 3.65 μM). FPP29 can be used for research on cancers such as liver cancer. (CPP: HY-P0133, VHL Ligand: HY-P11493, Linker: HY-W013664, FOXM1 Ligand: HY-P11494)

C145H228N56O32

3267.72

O=C(N[C@@H](CC1=CNC2=CC=CC=C12)C(N[C@@H](CC3=CNC4=CC=CC=C34)C(N[C@@H](CC(N)=O)C(N[C@@H]([C@H](O)C)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC5=CNC6=CC=CC=C56)C(NCC(N[C@@H](CO)C(N[C@@H](C)C(N[C@@H](CC(C)C)C(N[C@@H](C)C(N7[C@@H](CCC7)C(N[C@@H](CC8=CC=C(C=C8)O)C(N[C@@H]([C@@H](C)CC)C(N9[C@@H](CCC9)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](C)N

Apoptosis; DNA/RNA Synthesis; PROTACs

Von Hippel-Lindau (VHL)

Room temperature