FR 167653 free base [CAS 158876-65-4]

FR 167653 free base, an orally active and selective p38 MAPK inhibitor, is a potent suppressor of TNF-α and IL-1β production via specific inhibition of p38 MAPK activity. FR 167653 free base is effective in treating inflammation, relieving trauma and ischemia-reperfusion injury in vivo[1][2][3].

[158876-65-4]

C24H18FN5O2

427.43

O=C(N1NC2=C(C3=CC=NC=C3)C(C4=CC=C(F)C=C4)=NN2CC1)C(C5=CC=CC=C5)=O

Autophagy; p38 MAPK

10 mM in DMSO

Room temperature