Framycetin (sulfate) [CAS 4146-30-9]
Framycetin (sulfate) [CAS 4146-30-9]
SKU:QM-0154812-01
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Product Details
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Description
Framycetin sulfate (Neomycin B sulfate), an aminoglycoside antibiotic, is a potent RNase P cleavage activity inhibitor with a Ki of 35 μM. Framycetin sulfate competes for specific divalent metal ion binding sites in RNase P RNA. Framycetin sulfate inhibits hammerhead ribozyme with a Ki of 13.5 μM. Framycetin sulfate, a 5″-azido neomycin B precursor, binds the Drosha site in miR-525 and is used for hepatic encephalopathy and enteropathogenic E. coli infections[1][2].
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CAS Number
[4146-30-9]
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Molecular Formula
C23H52N6O25S3
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Molecular Weight
908.88
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Smiles
O=S(O)(O)=O.O=S(O)(O)=O.O=S(O)(O)=O.N[C@@H](C[C@H]1N)[C@@]([C@@H]([C@H]1O)O[C@@](O[C@H](CO)[C@H]2O[C@@]([C@@H]([C@@H](O)[C@@H]3O)N)([H])O[C@H]3CN)([H])[C@@H]2O)([H])O[C@H]([C@@H]([C@@H](O)[C@@H]4O)N)O[C@@H]4CN
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Target
Antibiotic; Bacterial
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Isoform
Aminoglycoside
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Purity
98
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Solubility
DMSO : < 1 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : 250 mg/mL (ultrasonic)
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Storage Conditions
4°C (Powder, sealed storage, away from moisture)
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Shipping Conditions
Room Temperature
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Hazard Statement
H302, H312, H332
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Precautions
H302, H312, H332
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Framycetin (sulfate) [CAS 4146-30-9]
Framycetin (sulfate) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.