FTO protein is an RNA demethylase that regulates fat mass, lipogenesis, and energy homeostasis by targeting N (6) -methyladenosine in mRNA. It also demethylates m6A in U6 snRNA and m6A (m) in 5'-cap, affecting mRNA stability. FTO Protein, Human (His) is the recombinant human-derived FTO protein, expressed by E. coli , with N-6*His labeled tag.