Ganciclovir triphosphate [CAS 86761-38-8]

Ganciclovir triphosphate (GCV-TP) is a synthetic 2'-deoxyguanosine analog with activity in inhibiting human cytomegalovirus (CMV) replication. Ganciclovir triphosphate is effective against CMV infection by binding to viral DNA polymerase and interfering with viral DNA synthesis. Ganciclovir triphosphate has an IC50 of 0.01 μM against CMV strains from humans, monkeys, mice, and guinea pigs. Ganciclovir triphosphate has also been used in gene-directed enzyme prodrug inhibition for cancer inhibition[1].

[86761-38-8]

C9H16N5O13P3

495.17

O=P(O)(OP(O)(OP(O)(O)=O)=O)OCC(OCN1C=NC2=C1N=C(N)NC2=O)CO

CMV; DNA/RNA Synthesis; Endogenous Metabolite

Room temperature