GAT564 [CAS 2851895-01-5]

GAT564 (Compound 15d) is a potent allosteric modulator of cannabinoid 1 receptor (CB1R) with EC50s of 87 and 320 nM respectively for cAMP and β-arrestin2. GAT564 markedly promotes orthosteric ligand binding to hCB1R. GAT564 is efficacious as a topical agent that significantly reduces intraocular pressure (IOP) in the ocular normotensive murine model of glaucoma[1].

[2851895-01-5]

C20H16N2O2S

348.42

O=[N+](CC(C1=C(NC2=CC=CC=C21)C3=CSC=C3)C4=CC=CC=C4)[O-]

Cannabinoid Receptor

10 mM in DMSO

Room temperature