GDC-0339 [CAS 1428569-85-0]

GDC-0339 is a potent, orally bioavailable and well tolerated pan-Pim kinase inhibitor, with Kis of 0.03 nM, 0.1 nM and 0.02 nM for Pim1, Pim2 and Pim3, respectively. GDC-0339 is discovered as a potential treatment of multiple myeloma[1][2].

[1428569-85-0]

C20H22F3N7OS

465.5

FC1=CC=CC(F)=C1C2=NC(C(NC3=C(N4CC[C@@H](F)[C@H](N)CC4)N(C)N=C3)=O)=C(N)S2

Pim

PIM1; PIM2; PIM3

10mM

99.87

DMSO : ≥ 52 mg/mL

-20°C, 3 years; 4°C, 2 years (Powder)

Room Temperature