GDCNF-11 [CAS 2991588-80-6]

GDCNF-11 is a HIM-PROTAC GPX4 degrader based on the chaperone protein HSP90. GDCNF-11 promotes the ubiquitination and degradation of GPX4 through the HSP 90 chaperone complex, reduces endogenous GPX4 expression to induce ferroptosis in HT-1080 cells, and the DC50 value is 0.08 μM (Pink: Target protein ligand ; Blue: HSP90 ligand (HY-10212) ; Black: Linker (HY-W169526) ).

[2991588-80-6]

C48H53Cl2N13O5S

994.99

NC1=NC(NCCC2CCN(CC2)C(CN3N=NC(COC4=C(C=C(C=C4)N(C(CCl)=O)C(C(NCCC5=CC=CC=C5)=O)C6=CC=CS6)Cl)=C3)=O)=C(C7=N1)N=CN7CC8=C(C(OC)=C(C=N8)C)C

Ferroptosis; Glutathione Peroxidase; PROTACs

GPX4

Room temperature