GDI2-IN-1

GDI2-IN-1 (compound (+) -37) is a GDP-dissociation inhibitor beta (GDI2) inhibitor with an IC50 of 2.87 μM and a KD of 36 μM. GDI2-IN-1 exhibits excellent in vivo antitumor activity in GDI2-overexpressing pancreatic xenograft models[1].

C42H47FN4O3

674.85

O[C@](C[C@@H]1C)(CC2=CN(CC3=CC=C(F)C=C3)N=N2)C[C@@]4([H])N1CCC5=C4C=C(OCC6=CC(C)=CC(C)=C6)C(OCC7=CC(C)=CC(C)=C7)=C5

ROCK

10 mM in DMSO

Room temperature